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통/번역
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행사-교육-코칭
기타
8.2. Dosing Schedule This is a single dose study. Patients will receive on two separate occasions a single palonosetron dose of 250g, once the administration is subcutaneous, intravenous in the other. The order of the route of administration will be allocated according to a randomization table. 8.2.1. Procedures medication administration The administration of medication will be as follows: - First cycle: sc or iv administration, 30-60 minutes before chemotherapy administration. - Second cycle: sc or iv infusion (the opposite way than first cycle), 30 - 60 minutes before the administration of chemotherapy The order of the route of administration depends on the randomization table. The administration will be in the abdomen when subcutaneously. In the case of intravenous administration, the same route may be used in place for administration of chemotherapy or other medications that the patient should receive as their medical criteria. Intravenous administration will be performed quickly, in 30 seconds, as described in the Product data sheet. Subcutaneous administration will also perform at this time, in the abdomen. 8.2.2. Washout Has established a washout period between the two administrations of 14 days, which is considered sufficient as the pharmacokinetic data observed palonosetron in the literature. 8.2.3. Precautions, antidotes Available emergency equipment and standard operating procedure for the treatment of non-specific reactions (allergy, anaphylactic shock). At all times there will be a doctor reachable to respond to unforeseen developments. 8.2.4. Procedures blind It is an open, not hidden treatments either the researchers nor the volunteers, but for those responsible for drug quantification analysis. 8.2.5. Concomitant medication The investigator assessed the impact on the study in the event that any of the volunteers had to receive some treatment concomitantly. Will try the two periods of administration of study medication are similar in concomitant medication. 8.2.6. Adherence Adherence will be secured by the research team, who directly administer the medication. Log the exact times of drug administration and removal of samples. 8.2 투여 일정 본 연구는 단일 용량 연구에 해당한다. 시험대상자들은 팔로노세트론 250의 단일 용량을 한 번은 피하주사로, 다른 한 번은 정맥주사로 각각 두 개의 국소부위에 투여받게 된다. 주사 경로의 순서는 무작위배정 표에 따라 배정된다. 8.2.1 시험약 투여 요법 시험약의 투여 요법은 아래와 같다: - 제1주기: 피하 또는 정맥 주사, 항암 주사요법 30-60분 전 투여. - 제2주기: 피하 또는 정맥 주입(제1주기와 반대 방법으로), 항암 주사요법 30-60분 전 투여 주사 경로의 순서는 무작위배정 표에 따라 결정된다. 피하일 경우 복부에 주사하도록 한다. 정맥주사의 경우에는, 항암 주사요법 혹은 의료기준에 따라 사용한 다른 약물에 사용된 부위와 같은 경로가 사용될 수 있다. 정맥주사는 신속하게, 30초 이내로, 약물 자료 시트의 설명에 따라 투여하여야 한다. 피하주사 역시 동일한 투여시간으로 복부에 투여한다. 8.2.2 휴약 현장에서 관찰된 팔로노셀트론이 약동학적 데이터로서 적절하게 고려될 수 있도록, 두 경로로의 주사투여 사이에 14일의 휴약 기간을 갖도록 한다. 8.2.3 주의사항, 해독제 비특이적 반응(알러지 반응, 아나필락틱 쇼크)의 치료를 위해 응급 장비 및 표준 작업 지침서를 갖추어야 한다. 예상치 못한 상황의 발전에 대응할 수 있도록 항상 임상시험 의사와 연락이 가능하도록 한다. 8.2.4 눈가림 절차 본 연구는 라벨 공개 연구로, 약물 정량 분석의 책임이 있는 연구자 및 지원자에게도 약물을 가리지 않는다. 8.2.5 병용 약물 연구자는 병용적 약물을 사용해야 했던 모든 지원자들의 반응이 연구에 미친 영향을 평가한다. 병용 약물과 유사한 시험 약물의 투여 경로 두 가지를 시도하도록 한다. 8.2.6 순응도 순응도는 약물을 직접 투여하는 연구팀에 의해 보존된다. 약물 투여 및 표본 제외의 정확한 횟수를 기록하도록 한다.
통/번역 영어
영한 샘플번역
참여요청
It’s been an interesting year for my bookshelf, or lack thereof. It’s the 8th year I’ve set a reading goal, and the most ambitious one yet. At the start of the year, I decided that I would read more on my (then) new iPhone X. Kindle and iBooks users will know this, but it’s pretty easy to get lost in the never ending vertical scroll, filled with books categorized by genres, bestsellers, sales, and upcoming writers. My choosing process is quite simple, I scroll to a book summary that appeals to me and I buy it. The best part of it is that as I scroll, tap, and purchase the book I don’t let the length of it affect my decision. The advent of e-reading has unearthed my insecurity regarding my book choice. Being a non-native, English-as-a-third-language speaker, I feared being seen with a book that’s under 200 pages. And if you’ve been to a bookstore in Korea lately, you’ll notice the trend of pocket books and the lack of hardcovers. I grew up in Cambodia where we had one bookstore that had the same bestsellers year after year, and one secondhand bookstore that was largely made up of books backpackers had left behind, or traded in for another worn paperback (lots of Stephen King). My actual bookstore existed only in airports. Overpriced books that you reluctantly buy if you forget to pack one for your flight. And growing up abroad, I spent a lot of time in it. It wasn’t until university that I found people who were avid readers as I am, who wanted to take the time to discuss and share what they read. It was also then that I decided I don’t belong in these discussions. Though my international education included a handful of the books that are considered classics, I’v never read through the list of “classics”. And that was enough to isolate me from book discussions. I stayed a closeted reader until I found out about Goodreads. It took a while for me to start sharing books that I’ve read, I’m reading, and I want to read. It’s so fascinating to be able to see, in real-time, what my Facebook friends are reading. I was particularly fascinated by this one friend, an acquaintance from university who took up 90% of my feed. She was starting a book, finishing a book, writing reviews, sharing quotes, almost every day. Her reading challenge for that year was 100! Mine was 30. Then one day, the feed didn’t update. I found out she had passed away. She never got to finish her Goodreads challenge, and I never got to thank her for changing my life. Her YOLO approach to whatever books she read inspired me to embrace the IDGAF attitude regarding book choices. When I ask around for book recommendations, the discussion and suggestions revolves around the 100 books you’re apparently supposed to read before you die. And when the books from that list doesn’t appeal to you, you’re not going to enjoy reading it. Society created a rubric, a prerequisite of books you have to read before you can call yourself a reader. I didn’t abide to it and thanks to that I achieved my 2018 reading challenge. That isn’t to say that I won’t read classics, it’s to say that I would like to read them as they fit my timeline. The final book that I’m ending the year with, my 52nd book of 2018, is I’d Rather Be Reading: The Delights and Dilemmas of the Reading Life, by Anne Bogel. A quote that speaks to me is, “when we share our favorite titles, we can’t help but share ourselves as well”, and so I would like to share myself. Here is my bookshelf. I would like to end with a quote highlighted by the aforementioned friend. I’m glad we crossed paths. We need never be hopeless, because we can never be irreparably broken. We think that we are invincible because we are. We cannot be born, and we cannot die. Like all energy, we can only change shapes and sizes and manifestations. They forget that when they get old. They get scared of losing and failing. But that part of us greater than the sum of our parts cannot begin and cannot end, and so it cannot fail.” — John Green.
마케팅-콘텐츠 마케팅
50 Books a Year
참여요청
기술 & 비즈니스 전문 번역가 노원빈입니다. 부산대학교에서 영어영문학을 전공했으며, IT 회사에서 약 2년 동안 근무하면서 경영전략(회계 및 마케팅)과 번역을 담당했습니다. 웹사이트와 브로슈어를 포함하여 다양한 텍스트를 번역하면서 번역을 시작하였고, 현재 열 군데가 넘는 에이전시 및 그룹에 등록되어 있습니다. 또한 기술과 비즈니스에 대하여 더 잘 알기 위해 지식재산학 학사 과정을 진행하고 있습니다. —— SOURCE TEXT (ENG) Telomeres are protective caps at the ends of chromosomes that become shorter with each cell division. If they become so short that the genes they protect could be damaged, the cell stops dividing and renewing. Consequently, the cell is increasingly unable to perform its functions. This mechanism is one of the ways in which we age. Telomere length is therefore regarded as a marker for the biological age of a person -- in contrast to their chronological age. For two people of the same chronological age, the person with shorter telomeres has an increased risk of developing age-related diseases such as Alzheimer's or cancer, and even a shorter life expectancy. Reference: Max Planck Institute for Human Cognitive and Brain Sciences. "Cellular aging is linked to structural changes in the brain: Telomeres on human chromosomes change together with brain structure." ScienceDaily. ScienceDaily, 27 September 2019. <www.sciencedaily.com/releases/2019/09/190927103248.htm>. TARGET TEXT (KOR) 텔로미어(Telomere)는 염색체 말단을 보호하는 염기서열로 세포가 분열할 때마다 소실된다. 텔로미어가 너무 짧아져 보호하고 있던 유전자가 손상될 정도에 이르면, 세포는 분열과 재생을 멈춘다. 그 결과, 세포는 점차 기능을 수행할 수 없게 된다. 이 메커니즘은 우리가 노화를 겪는 과정 중 하나이다. 따라서 텔로미어의 길이는 생활 연령과 차이가 있는 생물학적 연령의 표지로 간주된다. 같은 생활 연령이라 할지라도, 텔로미어가 짧은 사람은 알츠하이머나 암과 같은 노화 관련 질병이 발생 위험이 더 높고 기대 수명도 더 짧다.
통/번역 영어
생물학 분야 번역
참여요청
기술 & 비즈니스 전문 번역가 노원빈입니다. 부산대학교에서 영어영문학을 전공했으며, IT 회사에서 약 2년 동안 근무하면서 경영전략(회계 및 마케팅)과 번역을 담당했습니다. 웹사이트와 브로슈어를 포함하여 다양한 텍스트를 번역하면서 번역을 시작하였고, 현재 열 군데가 넘는 에이전시 및 그룹에 등록되어 있습니다. 또한 기술과 비즈니스에 대하여 더 잘 알기 위해 지식재산학 학사 과정을 진행하고 있습니다. —— [CHEMISTRY] Nobel Prize and Lithium-Ion Battery SOURCE TEXT (ENG) The foundation of the lithium-ion battery was laid during the oil crisis in the 1970s. Stanley Whittingham worked on developing methods that could lead to fossil fuel-free energy technologies. He started to research superconductors and discovered an extremely energy-rich material, which he used to create an innovative cathode in a lithium battery. This was made from titanium disulphide which, at a molecular level, has spaces that can house -- intercalate -- lithium ions. The battery's anode was partially made from metallic lithium, which has a strong drive to release electrons. This resulted in a battery that literally had great potential, just over two volts. However, metallic lithium is reactive and the battery was too explosive to be viable. John Goodenough predicted that the cathode would have even greater potential if it was made using a metal oxide instead of a metal sulphide. After a systematic search, in 1980 he demonstrated that cobalt oxide with intercalated lithium ions can produce as much as four volts. This was an important breakthrough and would lead to much more powerful batteries. Reference: Nobel Foundation. "Nobel Prize in Chemistry 2019: Lithium-ion batteries." ScienceDaily. ScienceDaily, 9 October 2019. <www.sciencedaily.com/releases/2019/10/191009082508.htm>. TARGET TEXT (KOR) 리튬 이온 배터리의 기반은 1970년대 석유파동 당시 마련되었다. 스탠리 휘팅엄은 화석 연료를 대체할 에너지 기술 개발에 몰두했다. 초전도체 연구를 시작한 휘팅엄은 극도로 고에너지 상태인 소재를 발견하여 리튬 배터리 음극 제작에 혁신을 일으켰다. 이황화 티타늄으로 만들어진 이 소재는 분자 수준에서 리튬 이온을 저장할 수 있는 공간을 가지고 있다. 배터리 양극의 일부분은 전자를 방출하는 강한 구동력을 가진 금속 리튬으로 만들어졌다. 휘팅엄은 이러한 방법으로 2볼트가 조금 넘는 엄청난 전위를 가진 배터리를 만들었다. 그러나 금속 리튬의 높은 반응성 때문에 배터리의 폭발성이 너무 커 상용화할 수 없었다. 존 구디너프는 황화 금속 대신 산화 금속을 사용한 배터리 음극이 훨씬 더 큰 전위를 가질 것이라고 예상했다. 그는 체계적인 조사 끝에 1980년에 리튬 이온을 저장할 수 있는 코발트 산화물이 최대 4볼트를 생산할 수 있다는 사실을 발표했다. 이 발견은 훨씬 더 강력한 배터리를 생산할 수 있는 중요한 돌파구였다.
통/번역 영어
화학 분야 번역
참여요청
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